- Fleury G, Masís-Vargas A, Kalsbeek A. Metabolic implications of exposure to light at night: a compilation of animal and human evidence. Obesity (Silver Spring). 2020 Jul;28 Suppl 1:S18-S28. 3.


- Masís-Vargas A, Ritsema W.I.G.R., Mendoza J, Kalsbeek A. Metabolic effects of light at night are time-and wavelength-dependent in rats. Obesity (Silver Spring). 2020 Jul;28 Suppl 1:S114-S125.

- Bagchi U, Gegnaw ST, Milićević N, et al. Core-clock genes Period 1 and 2 regulate visual cascade and cell cycle components during mouse eye development [published online ahead of print, 2020 Aug 12]. Biochim Biophys Acta Gene Regul Mech. 2020;1863(10):194623. doi:10.1016/j.bbagrm.2020.194623

- Mahdavi A, Qin Y, Aubry AS, Cornec D, Kulikova S, Pinault D. A single psychotomimetic dose of ketamine decreases thalamocortical spindles and delta oscillations in the sedated rat [published online ahead of print, 2020 Jun 4]. Schizophr Res. 2020;S0920-9964(20)30236-X. doi:10.1016/j.schres.2020.04.029

- Schueller E, Paiva I, Blanc F, Wang XL, et al. Dysregulation of histone acetylation pathways in hippocampus and frontal cortex of Alzheimer's disease patients. Eur Neuropsychopharmacol. 2020;33:101-116. doi:10.1016/j.euroneuro.2020.01.015

- Faivre F, Sánchez-Catalán MJ, Dovero S, ..., Joshi A,... et al. Ablation of the tail of the ventral tegmental area compensates symptoms in an experimental model of Parkinson's disease. Neurobiol Dis. 2020;139:104818. doi:10.1016/j.nbd.2020.104818

- Differential Coding Strategies in Glutamatergic and GABAergic Neurons in the Medial Cerebellar Nucleus. Orçun Orkan Özcan, Xiaolu Wang, Francesca Binda, Kevin Dorgans, Chris I. De Zeeuw, Zhenyu Gao, Ad Aertsen, Arvind Kumar, Philippe Isope. Journal of Neuroscience 2 January 2020, 40 (1) 159-170; DOI: 10.1523/JNEUROSCI.0806-19.2019


- Curr Biol. 2019 Dec 16;29(24):4268-4275.e7. doi: 10.1016/j.cub.2019.10.037. Epub 2019 Nov 27. Activity in Lateral Visual Areas Contributes to Surround Suppression in Awake Mouse V1. Vangeneugden J, van Beest EH, Cohen MX, Lorteije JAM, Mukherjee S, Kirchberger L, Montijn JS, Thamizharasu P, Camillo D, Levelt CN, Roelfsema PR, Self MW, Heimel JA.

- Masís-Vargas A, Hicks D, Kalsbeek A, Mendoza J. Blue light at night acutely impairs glucose tolerance and increases sugar intake in the diurnal rodent Arvicanthis ansorgei in a sex-dependent manner. Physiol Rep. 2019;7(20):e14257. doi:10.14814/phy2.14257

- Nemanja Milićević, Angelica Duursma, Anneloor L. M. A. ten Asbroek, Marie-Paule Felder-Schmittbuhl & Arthur A. Bergen (2019) Does the circadian clock make RPE-mediated ion transport “tick” via SLC12A2 (NKCC1)?, Chronobiology International, 36:11, 1592-1598, DOI: 10.1080/07420528.2019.1653317

- Milićević N, Mazzaro N, de Bruin I, et al. Rev-Erbα and Photoreceptor Outer Segments modulate the Circadian Clock in Retinal Pigment Epithelial Cells. Sci Rep. 2019;9(1):11790. Published 2019 Aug 13. doi:10.1038/s41598-019-48203-3

- Slomp M, Belegri E, Blancas-Velazquez AS, Diepenbroek C, Eggels L, Gumbs MCR, Joshi A, Koekkoek LL, Lamuadni K, Ugur M, Unmehopa UA, la Fleur SE, Mul JD. “Stressing the importance of choice: Validity of a preclinical free-choice high -caloric diet paradigm to model behavioral, physiological and molocular adaptations during human diet-induced obesity and metabolic dysfunction" J Neuroendocrinol. 2019 May;31(5):e12718. doi: 10.1111/jne.12718. Epub 2019 Apr 24. Review

- Morphine-dependent and abstinent mice are characterized by a broader distribution of the neurons co-expressing mu and delta opioid receptors. Pierre F, Ugur M, Faivre F, Doridot S, Veinante P, Massotte D. Neuropharmacology. 2019 Mar 8. pii: S0028-3908(19)30086-3. doi: 10.1016/j.neuropharm.2019.03.009.

- Kisspeptin and RFRP3 modulate body mass in Phodopus sungorus via two different neuroendocrine pathways. Cázarez-Márquez F, Milesi S, Laran-Chich MP, Klosen P, Kalsbeek A, Simonneaux V. J Neuroendocrinol. 2019 Mar 19:e12710. doi: 10.1111/jne.12710.

- Angelopoulou E., Quignon C, Kriegsfeld L. & Simonneaux V (2019). Functional implications of RFRP-3 in the central control of daily and seasonal rhythms in reproduction. Front Endo , in press.

- Brain Struct Funct. 2019 Jan 4. doi: 10.1007/s00429-018-01825-1. Cell-type specific parallel circuits in the bed nucleus of the stria terminalis and the central nucleus of the amygdala of the mouse. Ye J, Veinante P.

- Regulation of Brain DNA Methylation Factors and of the Orexinergic System by Cocaine and Food Self-Administration. Saad L, Sartori M, Pol Bodetto S, Romieu P, Kalsbeek A, Zwiller J, Anglard P. Mol Neurobiol. 2019 Jan 2. doi: 10.1007/s12035-018-1453-6. [Epub ahead of print] PMID:30603957

- The hidden side of Parkinson's disease: Studying pain, anxiety and depression in animal models. Faivre F, Joshi A, Bezard E, Barrot M. Neurosci Biobehav Rev. 2019 Jan;96:335-352. doi:10.1016/j.neubiorev.2018.10.004. Epub 2018 Oct 23.Review. PMID: 30365972


- Ugur M., Derouiche L. and Massotte D. (2018) “Heteromerization modulates mu opioid receptor functional properties in vivo.” Frontiers in Pharmacology 9, 1240.

- Bagchi U, Micheal S, Siddiqui SN, Khan MI, Ten Brink JB, Felder-Schmittbuhl MP, Bergen AA. Mutation analysis of circadian clock gene BMAL1 in 21 Pakistani congenital cataract families. Clin. Invest. (Lond.) (2019) 9(1), 1-3. doi: 10.4172/ Clinical-Investigation.1000144©2019

- Wei Y, Ramautar JR, Colombo MA, Te Lindert BHW, Van Someren EJW. EEG Microstates Indicate Heightened Somatic Awareness in Insomnia: Toward Objective Assessment of Subjective Mental Content. Front Psychiatry. 2018;9:395. Published 2018 Sep 6. doi:10.3389/fpsyt.2018.00395

- Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A. Nguyen TL, Duchon A, Manousopoulou A, Loaëc N, Villiers B, Pani G, Karatas M, Mechling AE, Harsan LA, Limanton E, Bazureau JP, Carreaux F, Garbis SD, Meijer L, Herault Y. Dis Model Mech. 2018 Aug 16. pii: dmm.035634. doi: 10.1242/dmm.03563.

- Sustained effects of prior red light on pupil diameter and vigilance during subsequent darkness. van der Meijden WP, Te Lindert BHW, Ramautar JR, Wei Y, Coppens JE, Kamermans M, Cajochen C, Bourgin P, Van Someren EJW. Proc Biol Sci. 2018 Jul 18;285(1883). pii: 20180989. doi: 10.1098/rspb.2018.0989.

- Ehrlich AT, Semache M, Bailly J, ..., Arefin TM, et al. Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing. Brain Struct Funct. 2018;223(3):1275-1296. doi:10.1007/s00429-017-1547-3



- Itzhacki J, Clesse D, Goumon Y, Van Someren EJ, Mendoza J. Light rescues circadian behavior and brain dopamine abnormalities in diurnal rodents exposed to a winter-like photoperiod. Brain Struct Funct. 2018 Mar 20. doi: 10.1007/s00429-018-1655-8.

- Increased Alcohol Seeking in Mice Lacking Gpr88 Involves Dysfunctional Mesocorticolimbic Networks. Ben Hamida S, Netto S, Arefin TM, Nasseef T, Boulos L, McNicholas M, Ehrlich A, Moquin L, Gratton A, Darcq E, Harsan L-A, Maldonado R, and Kieffer BL. Biological Psychiatry (2018), https://doi.org/10.1016/j.biopsych.2018.01.026

- Lack of anticipatory behavior in Gpr88 knockout mice showed by automatized home cage phenotyping. Maroteaux G*, Arefin TM*, Harsan L-A, Darcq E, Ben Hamida S, Kieffer BL. Genes, Brain and Behavio. 2018; e12473. https://doi.org/10.1111/gbb.12473

- A Free-Choice High-Fat High-Sugar Diet Alters Day-Night Per2 Gene Expression in Reward-Related Brain Areas in Rats. Blancas-Velazquez AS, Unmehopa UA, Eggels L, Koekkoek L, Kalsbeek A, Mendoza J, la Fleur SE. Front Endocrinol (Lausanne). 2018 Apr 9;9:154. doi:10.3389/fendo.2018.00154. eCollection 2018.

- Environmental light and time of day modulate subjective liking and wanting. Itzhacki J, Te Lindert BHW, van der Meijden WP, Kringelbach ML, Mendoza J, Van Someren EJW. Emotion. 2018 Mar 5. doi: 10.1037/emo0000402. [Epub ahead of print]

- Sellmeijer J, Mathis V, Hugel S, Li XH, Song Q, Chen QY, Barthas F, Lutz PE, Karatas M, Luthi A, Veinante P, Aertsen A, Barrot M, Zhuo M, Yalcin I. Hyperactivity of anterior cingulate cortex areas 24a/24b drives chronic pain-induced anxiodepressive-like consequences. J Neurosci. 2018 Feb 20. pii: 3195-17. doi: 10.1523/JNEUROSCI.3195-17.2018. [Epub ahead of print]

- Bright environmental light ameliorates deficient subjective liking in insomnia: an experience sampling study. Te Lindert BHW, Itzhacki J, van der Meijden WP, Kringelbach ML, Mendoza J, Van Someren EJW. Sleep. 2018 Feb 7. doi: 10.1093/sleep/zsy022.

- Paul de Goede, Satish Sen, Johanneke E. Oosterman, Ewout Foppen, Remi Jansen, Susanne E. la Fleur, Etienne Challet, Andries Kalsbeek. Differential effects of diet composition and timing of feeding behavior on rat brown adipose tissue and skeletal muscle peripheral clocks. Neurobiology of Sleep and Circadian Rhythms. Volume 4, 2018, Pages 24-33, ISSN 2451-9944, https://doi.org/10.1016/j.nbscr.2017.09.002.

- Expression of the clock gene Rev-erbα in the brain controls the circadian organisation of food intake and locomotor activity, but not daily variations of energy metabolism. Sen S, Dumont S, Sage-Ciocca D, Reibel S, de Goede P, Kalsbeek A, Challet E. J Neuroendocrinol. 2018 Jan;30(1). doi: 10.1111/jne.12557.


- Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing. Ehrlich AT, Semache M, Bailly J, Wojcik S, Arefin TM, Colley C, Le Gouill C, Gross F, Lukasheva V, Hogue M, Darcq E, Harsan LA, Bouvier M, Kieffer BL. Brain Struct Funct. 2017 Nov 6. doi: 10.1007/s00429-017-1547-3. [Epub ahead of print]

- Remodeling of Sensorimotor Brain Connectivity in Gpr88-Deficient Mice. Arefin TM, Mechling AE, Meirsman AC, Bienert T, Hübner NS, Lee HL, Ben Hamida S, Ehrlich A, Roquet D, Hennig J, von Elverfeldt D, Kieffer BL, Harsan LA. Brain Connect. 2017 Oct;7(8):526-540. doi: 10.1089/brain.2017.0486.

- Simonneaux V, Bahougne T, Angelopoulou E. Daily rhythms count for female fertility. Best Pract Res Clin Endocrinol Metab (2017) Oct;31(5):505-519.

- Sleep Stage Transition Dynamics Reveal Specific Stage 2 Vulnerability in Insomnia. Wei Y, Colombo MA, Ramautar JR, Blanken TF, van der Werf YD, Spiegelhalder K, Feige B, Riemann D, Van Someren EJW. Sleep. 2017 Sep 1;40(9). doi: 10.1093/sleep/zsx117.

- Cingulate Overexpression of Mitogen-Activated Protein Kinase Phosphatase-1 as a Key Factor for Depression. Barthas F, Humo M, Gilsbach R, Waltisperger E, Karatas M, Leman S, Hein L, Belzung C, Boutillier AL, Barrot M, Yalcin I. Biol Psychiatry. 2017 Sep 1;82(5):370-379. doi: 10.1016/j.biopsych.2017.01.019. Epub 2017 Feb 14.


- Effects of a free-choice high-fat high-sugar diet on brain PER2 and BMAL1 protein expression in mice. Blancas-Velazquez A, la Fleur SE, Mendoza J. Appetite. 2017 Oct 1;117:263-269. doi: 10.1016/j.appet.2017.07.002. Epub 2017 Jul 5.

- Spreizer S, Angelhuber M, Bahuguna J, Aertsen A, Kumar A. Activity Dynamics and Signal Representation in a Striatal Network Model with Distance-Dependent Connectivity. eNeuro. 2017;4(4):ENEURO.0348-16.2017. doi:10.1523/ENEURO.0348-16.2017.

- El Oussini, H., Scekic-Zahirovic, J., Vercruysse, P., Marques, C., Dirrig-Grosch, S., Dieterlé, S., Picchiarelli, G., Sinniger, J., Rouaux, C. and Dupuis, L. (2017), Degeneration of serotonin neurons triggers spasticity in amyotrophic lateral sclerosis. Ann Neurol., 82: 444–456. doi:10.1002/ana.25030

- Sleep Deprivation and Caffeine Treatment Potentiate Photic Resetting of the Master Circadian Clock in a Diurnal Rodent. Pawan Kumar Jha, Hanan Bouâouda, Sylviane Gourmelen, Stephanie Dumont, Fanny Fuchs, Yannick Goumon, Patrice Bourgin, Andries Kalsbeek, Etienne Challet Journal of Neuroscience 19 April 2017, 37 (16) 4343-4358; DOI: 10.1523/JNEUROSCI.3241-16.2017

- Ultradian feeding in mice not only affects the peripheral clock in the liver, but also the master clock in the brain. Sen S, Raingard H, Dumont S, Kalsbeek A, Vuillez P, Challet E. Chronobiol Int. 2017;34(1):17-36. doi: 10.1080/07420528.2016.1231689. Epub 2016 Sep 26.

- Motor neuron intrinsic and extrinsic mechanisms contribute to the pathogenesis of FUS-associated amyotrophic lateral sclerosis. Scekic-Zahirovic J, Oussini HE, Mersmann S, Drenner K, Wagner M, Sun Y, Allmeroth K, Dieterlé S, Sinniger J, Dirrig-Grosch S, René F, Dormann D, Haass C, Ludolph AC, Lagier-Tourenne C, Storkebaum E, Dupuis L. Acta Neuropathol. 2017 Jun;133(6):887-906. doi: 10.1007/s00401-017-1687-9. Epub 2017 Feb 28.

- Motor Learning Requires Purkinje Cell Synaptic Potentiation through Activation of AMPA-Receptor Subunit GluA3. Gutierrez-Castellanos N, Da Silva-Matos CM, Zhou K, Canto CB, Renner MC, Koene LMC, Ozyildirim O, Sprengel R, Kessels HW, De Zeeuw CI. Neuron. 2017 Jan 18;93(2):409-424. doi: 10.1016/j.neuron.2016.11.046.

- Rev-erbα modulates the hypothalamic orexinergic system to influence pleasurable feeding behaviour in mice. Feillet CA, Bainier C, Mateo M, Blancas-Velázquez A, Salaberry NL, Ripperger JA, Albrecht U, Mendoza J. Addict Biol. 2017 Mar;22(2):411-422. doi: 10.1111/adb.12339. Epub 2015 Dec 2.

- Diet-Induced Obesity and Circadian Disruption of Feeding Behavior. Blancas-Velazquez A, Mendoza J, Garcia AN, la Fleur SE. Front Neurosci. 2017 Feb 7;11:23. doi: 10.3389/fnins.2017.00023. eCollection 2017. Review.


- More Severe Insomnia Complaints in People with Stronger Long-Range Temporal Correlations in Wake Resting-State EEG. Colombo MA, Wei Y, Ramautar JR, Linkenkaer-Hansen K, Tagliazucchi E, Van Someren EJ. Front Physiol. 2016 Nov 29;7:576. eCollection 2016.

- Jha PK, Foppen E, Kalsbeek A, Challet E. Sleep restriction acutely impairs glucose tolerance in rats. Physiological Reports. 2016;4(12):e12839. doi:10.14814/phy2.12839.

- The Roles of the Olivocerebellar Pathway in Motor Learning and Motor Control. A Consensus Paper. Lang EJ, Apps R, Bengtsson F, Cerminara NL, De Zeeuw CI, Ebner TJ, Heck DH, Jaeger D, Jörntell H, Kawato M, Otis TS, Ozyildirim O, Popa LS, Reeves AM, Schweighofer N, Sugihara I, Xiao J. Cerebellum. 2017 Feb;16(1):230-252. doi: 10.1007/s12311-016-0787-8.


- Alterations in the hypothalamic melanocortin pathway in amyotrophic lateral sclerosis. Vercruysse P, Sinniger J, El Oussini H, Scekic-Zahirovic J, Dieterlé S, Dengler R, Meyer T, Zierz S, Kassubek J, Fischer W, Dreyhaupt J, Grehl T, Hermann A, Grosskreutz J, Witting A, Van Den Bosch L, Spreux-Varoquaux O; GERP ALS Study Group, Ludolph AC, Dupuis L. Brain. 2016 Apr;139(Pt 4):1106-22. doi: 10.1093/brain/aww004. Epub 2016 Mar 16.

- Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss. Scekic-Zahirovic J, Sendscheid O, El Oussini H, Jambeau M, Sun Y, Mersmann S, Wagner M, Dieterlé S, Sinniger J, Dirrig-Grosch S, Drenner K, Birling MC, Qiu J, Zhou Y, Li H, Fu XD, Rouaux C, Shelkovnikova T, Witting A, Ludolph AC, Kiefer F, Storkebaum E, Lagier-Tourenne C, Dupuis L. EMBO J. 2016 May 17;35(10):1077-97. doi: 10.15252/embj.201592559. Epub 2016 Mar 7.


- El Oussini, H., Bayer, H., Scekic-Zahirovic, J. et al. Acta Neuropathol (2016) 131: 465. https://doi.org/10.1007/s00401-016-1534-4.


- Bruijel J, van der Meijden WP, Bijlenga D, Dorani F, Coppens JE, te Lindert BH, Kooij JJ, Van Someren EJW. Individual differences in the post-illumination pupil response to blue light: assessment without mydriatics. Biology 2016; 5:34.


- Wei Y, Ramautar JR, Colombo MA, Stoffers D, Gómez-Herrero G, van der Meijden WP, te Lindert BH, van der Werf YD, Van Someren EJ. I keep a close watch on this heart of mine: increased interoception in insomnia. Sleep 2016; 39:2113-2124.

- Mechling AE, Arefin T, Lee H-L, et al. Deletion of the mu opioid receptor gene in mice reshapes the reward–aversion connectome. Proceedings of the National Academy of Sciences of the United States of America. 2016;113(41):11603-11608. doi:10.1073/pnas.1601640113.

- van der Meijden WP, Van Someren JL, te Lindert BHW, van Oosterhout F, Coppens JE, Kalsbeek A, Cajochen C, Bourgin P and Van Someren EJW. Individual differences in sleep timing relate to melanopsin-based phototransduction in healthy adolescents and young adults. Sleep 2016; 39:1305-1310.

- Wake High-Density Electroencephalographic Spatiospectral Signatures of Insomnia. Colombo MA, Ramautar JR, Wei Y, Gomez-Herrero G, Stoffers D, Wassing R, Benjamins JS, Tagliazucchi E, van der Werf YD, Cajochen C, Van Someren EJ. Sleep. 2016 May 1;39(5):1015-27. doi: 10.5665/sleep.5744.


- Kumar Jha P, Challet E, Kalsbeek A. Circadian rhythms in glucose and lipid metabolism in nocturnal and diurnal mammals. Mol Cell Endocrinol. 2015 Dec 15;418 Pt 1:74-88.


- Jha PK, Foppen E, Challet E, Kalsbeek A. Effects of central gastrin-releasing peptide on glucose metabolism. Brain Res. 2015 Nov 2;1625:135-41.


- van der Meijden WP, te Lindert BH, Bijlenga D, Coppens JE, Gómez-Herrero G, Bruijel J, Kooij JJ, Cajochen C, Bourgin P, Van Someren Post-illumination pupil response after blue light: Reliability of optimized melanopsin-based phototransduction assessment. EJExp Eye Res. 2015 Oct;139:73-80.


- van der Meijden WP, Fronczek R, Reijntjes RH, Corssmit EP, Biermasz NR, Lammers GJ, van Dijk JG, Thijs RD. Time- and state-dependent analysis of autonomic control in narcolepsy: higher heart rate with normal heart rate variability independent of sleep fragmentation.

J Sleep Res. 2015 Apr;24(2):206-14.


- Barthas F, Sellmeijer J, Hugel S, Waltisperger E, Barrot M, Yalcin I. The anterior cingulate cortex is a critical hub for pain-induced depression. Biol Psychiatry. 2015 Feb 1;77(3):236-45.



- Han SM, El Oussini H, Scekic-Zahirovic J, Vibbert J, Cottee P, Prasain JK, Bellen HJ, Dupuis L, Miller MA. VAPB/ALS8 MSP ligands regulate striated muscle energy metabolism critical for adult survival in caenorhabditis elegans. PLoS Genet. 2013;9(9):e1003738.

- J. Benjamins, F. Migliorati, K. Dekker, R. Wassing, S. Moens, E. Van Someren, L. Hartescu, J. Itzhacki, T. Pinto, N. Tesler, J. Perrier, C. Garbazza, M. Jarkiewicz. The sleep registry. An international online survey and cognitive test assessment tool and database for multivariate sleep and insomnia phenotyping. Sleep Medicine, Volume 14, Supplement 1, December 2013, Pages e293-e294


- Romeijn N, Raymann RJ, Møst E, Te Lindert B, Van Der Meijden WP, Fronczek R, Gomez-Herrero G, Van Someren. Sleep, vigilance, and thermosensitivity. EJ.Pflugers Arch. 2012 Jan;463(1):169-76.

Scientific papers

published in the framework of the NeuroTime programme