Jelena ŠĆEKIĆ-ZAHIROVIĆ

Montenegrin citizen

VAPB/ALS8 in the selective vulnerability of motoneruonal populations in amyotrophic lateral sclerosis

 

Supervision:

- Luc DUPUIS: Inserm U692/Unistra, Strasbourg, France

- Marlene BARTOS: BCF/ALUF, Freiburg, Germany

- Pico CARONI: FMI/UniBas, Basel, Switzerland

PhD thesis defended: January 11th 2016 - Strasbourg, France

 

Current position:

Postdoctoral Researcher

French Inst. of Health and Medical Research, INSERM / Central and peripheral mechanisms of neurodegeneration, Strasbourg (France)

NeuroTime Publications:

- El Oussini, H., Scekic-Zahirovic, J., Vercruysse, P., Marques, C., Dirrig-Grosch, S., Dieterlé, S., Picchiarelli, G., Sinniger, J., Rouaux, C. and Dupuis, L. (2017), Degeneration of serotonin neurons triggers spasticity in amyotrophic lateral sclerosis. Ann Neurol., 82: 444–456. doi:10.1002/ana.25030

- Motor neuron intrinsic and extrinsic mechanisms contribute to the pathogenesis of FUS-associated amyotrophic lateral sclerosis. Scekic-Zahirovic J, Oussini HE, Mersmann S, Drenner K, Wagner M, Sun Y, Allmeroth K, Dieterlé S, Sinniger J, Dirrig-Grosch S, René F, Dormann D, Haass C, Ludolph AC, Lagier-Tourenne C, Storkebaum E, Dupuis L. Acta Neuropathol. 2017 Jun;133(6):887-906. doi: 10.1007/s00401-017-1687-9. Epub 2017 Feb 28.

- Alterations in the hypothalamic melanocortin pathway in amyotrophic lateral sclerosis. Vercruysse P, Sinniger J, El Oussini H, Scekic-Zahirovic J, Dieterlé S, Dengler R, Meyer T, Zierz S, Kassubek J, Fischer W, Dreyhaupt J, Grehl T, Hermann A, Grosskreutz J, Witting A, Van Den Bosch L, Spreux-Varoquaux O; GERP ALS Study Group, Ludolph AC, Dupuis L. Brain. 2016 Apr;139(Pt 4):1106-22. doi: 10.1093/brain/aww004. Epub 2016 Mar 16.

​- Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss. Scekic-Zahirovic J, Sendscheid O, El Oussini H, Jambeau M, Sun Y, Mersmann S, Wagner M, Dieterlé S, Sinniger J, Dirrig-Grosch S, Drenner K, Birling MC, Qiu J, Zhou Y, Li H, Fu XD, Rouaux C, Shelkovnikova T, Witting A, Ludolph AC, Kiefer F, Storkebaum E, Lagier-Tourenne C, Dupuis L. EMBO J. 2016 May 17;35(10):1077-97. doi: 10.15252/embj.201592559. Epub 2016 Mar 7.

- El Oussini, H., Bayer, H., Scekic-Zahirovic, J. et al. Acta Neuropathol (2016) 131: 465.https://doi.org/10.1007/s00401-016-1534-4.

- Han SM, El Oussini H, Scekic-Zahirovic J, Vibbert J, Cottee P, Prasain JK, Bellen HJ, Dupuis L, Miller MA. VAPB/ALS8 MSP ligands regulate striated muscle energy metabolism critical for adult survival in caenorhabditis elegans. PLoS Genet. 2013;9(9):e1003738.

Tiago FELIX

Brazilian citizen

Dissecting the auditory cortical circuitry: influence of dendritic vs. perisomatic inhibition on network oscillations

 

Supervision:

- Marlene BARTOS: BCF/ALUF, Freiburg, Germany

- Andreas LÜTHI: FMI/UniBas, Basel, Switzerland

- Didier PINAULT: Inserm U666/Unistra, Strasbourg, France

PhD thesis defended: July 20th 2016 - Freiburg, Germany

Current position:

Research Audiologist and Digital Signal Processing (DSP) Engineer

Cochlear / Hannover (Germany)

Ӧzgecan ӦZYILDIRIM

Turkish citizen

Role of excitatory cerebellar interneurones in learning-dependent timing

 

Supervision:

- Chris DE ZEEUW: NIN/UvA, Amsterdam, The Netherlands

- Peter SCHEIFFELE: Biozentrum, UniBas, Basel, Switzerland

- Ad AERTSEN: BCF/ALUF, Freiburg, Germany

NeuroTime Publications:

- Motor Learning Requires Purkinje Cell Synaptic Potentiation through Activation of AMPA-Receptor Subunit GluA3. Gutierrez-Castellanos N, Da Silva-Matos CM, Zhou K, Canto CB, Renner MC, Koene LMC, Ozyildirim O, Sprengel R, Kessels HW, De Zeeuw CI. Neuron. 2017 Jan 18;93(2):409-424. doi: 10.1016/j.neuron.2016.11.046.

- The Roles of the Olivocerebellar Pathway in Motor Learning and Motor Control. A Consensus Paper. Lang EJ, Apps R, Bengtsson F, Cerminara NL, De Zeeuw CI, Ebner TJ, Heck DH, Jaeger D, Jörntell H, Kawato M, Otis TS, Ozyildirim O, Popa LS, Reeves AM, Schweighofer N, Sugihara I, Xiao J. Cerebellum. 2017 Feb;16(1):230-252. doi: 10.1007/s12311-016-0787-8.

Tanzil AREFIN

Bangladeshi citizen

Patterns of neurocircuitries modification in alcoholism: in vivo assessment in mouse models of alcohol addiction

 

Supervision:

- Brigitte KIEFFER: IGBMC/Unistra, Strasbourg, France

- Jürgen HENNIG: BCF/ALUF, Freiburg, Germany

PhD thesis defended: November 20th 2017 - Strasbourg, France

Current position:

Postdoctoral Researcher

Center for Advanced Imaging Innovation & Research, CAI2R / Department of Radiology, NYU School of Medicine, New York (USA)

NeuroTime Publications:

- Increased Alcohol Seeking in Mice Lacking Gpr88 Involves Dysfunctional Mesocorticolimbic Networks. Ben Hamida S, Netto S, Arefin TM, Nasseef T, Boulos L, McNicholas M, Ehrlich A, Moquin L, Gratton A, Darcq E, Harsan L-A, Maldonado R, and Kieffer BL. Biological Psychiatry (2018), https://doi.org/10.1016/j.biopsych.2018.01.026

- Lack of anticipatory behavior in Gpr88 knockout mice showed by automatized home cage phenotyping. Maroteaux G*, Arefin TM*, Harsan L-A, Darcq E, Ben Hamida S, Kieffer BL. Genes, Brain and Behavio. 2018; e12473. https://doi.org/10.1111/gbb.12473

- Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing. Ehrlich AT, Semache M, Bailly J, Wojcik S, Arefin TM, Colley C, Le Gouill C, Gross F, Lukasheva V, Hogue M, Darcq E, Harsan LA, Bouvier M, Kieffer BL. Brain Struct Funct. 2017 Nov 6. doi: 10.1007/s00429-017-1547-3. [Epub ahead of print]

​- Remodeling of Sensorimotor Brain Connectivity in Gpr88-Deficient Mice. Arefin TM, Mechling AE, Meirsman AC, Bienert T, Hübner NS, Lee HL, Ben Hamida S, Ehrlich A, Roquet D, Hennig J, von Elverfeldt D, Kieffer BL, Harsan LA. Brain Connect. 2017 Oct;7(8):526-540. doi: 10.1089/brain.2017.0486.

- Mechling AE, Arefin T, Lee H-L, et al. Deletion of the mu opioid receptor gene in mice reshapes the reward–aversion connectome. Proceedings of the National Academy of Sciences of the United States of America. 2016;113(41):11603-11608. doi:10.1073/pnas.1601640113.

Wisse VAN DER MEIJDEN

Dutch citizen

The alerting effect of light: modification by behavioural state, circadian cycle and individual differences

 

Supervision:

- Eus VAN SOMEREN: NIN/UvA, Amsterdam, The Netherlands

- Patrice BOURGIN: INCI/Unistra, Strasbourg France

- Christian CAJOCHEN: UPK/UniBas, Basel, Switzerland

PhD thesis defended: September 19th 2018 - the Aula, University of Amsterdam, the Netherlands

NeuroTime Publications:

- Sustained effects of prior red light on pupil diameter and vigilance during subsequent darkness. van der Meijden WP, Te Lindert BHW, Ramautar JR, Wei Y, Coppens JE, Kamermans M, Cajochen C, Bourgin P, Van Someren EJW. Proc Biol Sci. 2018 Jul 18;285(1883). pii: 20180989. doi: 10.1098/rspb.2018.0989.

- Environmental light and time of day modulate subjective liking and wanting. Itzhacki J, Te Lindert BHW, van der Meijden WP, Kringelbach ML, Mendoza J, Van Someren EJW. Emotion. 2018 Mar 5. doi: 10.1037/emo0000402. [Epub ahead of print]

- Bright environmental light ameliorates deficient subjective liking in insomnia: an experience sampling study. Te Lindert BHW, Itzhacki J, van der Meijden WP, Kringelbach ML, Mendoza J, Van Someren EJW. Sleep. 2018 Feb 7. doi: 10.1093/sleep/zsy022.

- Bruijel J, van der Meijden WP, Bijlenga D, Dorani F, Coppens JE, te Lindert BH, Kooij JJ, Van Someren EJW. Individual differences in the post-illumination pupil response to blue light: assessment without mydriatics. Biology 2016; 5:34.

- van der Meijden WP, Van Someren JL, te Lindert BHW, van Oosterhout F, Coppens JE, Kalsbeek A, Cajochen C, Bourgin P and Van Someren EJW. Individual differences in sleep timing relate to melanopsin-based phototransduction in healthy adolescents and young adults. Sleep 2016; 39:1305-1310.

- van der Meijden WP, te Lindert BH, Bijlenga D, Coppens JE, Gómez-Herrero G, Bruijel J, Kooij JJ, Cajochen C, Bourgin P, Van Someren Post-illumination pupil response after blue light: Reliability of optimized melanopsin-based phototransduction assessment. EJExp Eye Res. 2015 Oct;139:73-80.

- van der Meijden WP, Fronczek R, Reijntjes RH, Corssmit EP, Biermasz NR, Lammers GJ, van Dijk JG, Thijs RD. Time- and state-dependent analysis of autonomic control in narcolepsy: higher heart rate with normal heart rate variability independent of sleep fragmentation.

J Sleep Res. 2015 Apr;24(2):206-14.

- Romeijn N, Raymann RJ, Møst E, Te Lindert B, Van Der Meijden WP, Fronczek R, Gomez-Herrero G, Van Someren. Sleep, vigilance, and thermosensitivity. EJ.Pflugers Arch. 2012 Jan;463(1):169-76.

Martin ANGELHUBER

German citizen

The neuronal circuitry of fear conditioning: Computing at the interface between cortex and striatum

 

Supervision:

- Ad AERTSEN: BCF/ALUF, Freiburg, Germany

- Andreas LÜTHI: FMI/UniBas, Basel, Switzerland

- Pierre VEINANTE: INCI/Unistra, Strasbourg, France

PhD thesis defended: October 27th 2016 - Freiburg, Germany

Publications:

- Spreizer S, Angelhuber M, Bahuguna J, Aertsen A, Kumar A. Activity Dynamics and Signal Representation in a Striatal Network Model with Distance-Dependent Connectivity. eNeuro. 2017;4(4):ENEURO.0348-16.2017. doi:10.1523/ENEURO.0348-16.2017.

NeuroTime students of the 1st Edition (2012)

Pawan JHA

​Indian citizen

Effects of the sleep deprivation on circadian and metabolic rhythmicity in a diurnal rodent

 

Supervision:

- Etienne CHALLET: INCI CNRS UPR3212/Unistra, Strasbourg, France

- Andries KALSBEEK: NIN/UvA, Amsterdam, The Netherlands

PhD thesis defended: July 6th 2016 - Strasbourg, France

Current position:

Postdoctoral Researcher

Molecular, cellular and circuit mechanism of sleep / University of Pennsylvania (USA)

(Biological clocks and sleep research laboratory / The Francis Crick Institute, London (UK))

NeuroTime Publications:

- Sleep Deprivation and Caffeine Treatment Potentiate Photic Resetting of the Master Circadian Clock in a Diurnal Rodent. Pawan Kumar Jha, Hanan Bouâouda, Sylviane Gourmelen, Stephanie Dumont, Fanny Fuchs, Yannick Goumon, Patrice Bourgin, Andries Kalsbeek, Etienne Challet Journal of Neuroscience 19 April 2017, 37 (16) 4343-4358; DOI: 10.1523/JNEUROSCI.3241-16.2017

- Jha PK, Foppen E, Kalsbeek A, Challet E. Sleep restriction acutely impairs glucose tolerance in rats. Physiological Reports. 2016;4(12):e12839. doi:10.14814/phy2.12839.

- Jha PK, Foppen E, Challet E, Kalsbeek A. Effects of central gastrin-releasing peptide on glucose metabolism. Brain Res. 2015 Nov 2;1625:135-41.

- Kumar Jha P, Challet E, Kalsbeek A. Circadian rhythms in glucose and lipid metabolism in nocturnal and diurnal mammals. Mol Cell Endocrinol. 2015 Dec 15;418 Pt 1:74-88.

NeuroTime students of the 1st Edition at the 1st Annual Meeting in Beuggen, Jan. 2013. (Photo: Janina Kirsch)

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